Tonometry and biomechanics of the cornea in contact lens wear

Booysen, Dirk (2016). Tonometry and biomechanics of the cornea in contact lens wear. PHD thesis, Aston University.


Aims: Research on use of contact lenses as drug delivery systems continues. Disposable lenses are often used to treat corneal injuries. Accurate intraocular pressure (IOP) measurements with lenses in situ will enhance patient care and save valuable chair time.Inter- and intraobserver reliability of rebound tonometer (RBT) and intraobserver reliability of ocular response analyser (ORA) with and without contact lenses of 50 (15 male, 35 female) healthy well adapted contact lens wearers between 18 – 55 years (M = 38.90, SD = 9.23) were examined. Clinical comparisons of IOP measurements with ORA and RBT were done. Accuracy of IOP measurements with four commonly prescribed disposable contact lenses (Acuvue Oasys, Frequency XC, Acuvue 1-Day Moist, and Pure Vision with powers -6.00 − +6.00 D) in situ was evaluated. Physiological and physical factors influencing IOP measurements with both instruments were determined. Findings: Intraobserver reliability of RBT without and with lenses was excellent (ICC > 0.88; > 0.92 respectively). Interobserver reliability of RBT was excellent without or with lenses (ICC 0.81; 0.88 respectively). Intraobserver reliability of ORA was good for all metrics measured except for corneal hysteresis (CH) (ICC: CH 0.63; corneal resistance factor (CRF) 0.79; corneal compensated IOP (IOPcc) 0.77; IOPg 0.87).RBT and ORA IOPg (Goldmann equivalent IOP) measurements were clinically and statistically comparable without or with lenses (differences < 0.6 mmHg). ORA IOPcc and RBT were less comparable (differences < 1.45 mmHg).Accurate RBT and ORA tonometry (within 2 mmHg) was possible with low minus power (range -0.50 to -6.00 D); moderate modulus of elasticity (< 0.75 MPa); thin silicone hydrogel (Acuvue Oasys) and hydrogel (Frequency XC; Acuvue 1-Day Moist) contact lenses in situ.Multiple regression analyses showed biomechanical metrics CRF and CH affected RBT and ORA (IOPcc and IOPg) measurements strongly (p < 0.0001). Therefore, cornea’s biomechanical properties had greater influence on accuracy of IOP measurements with these two instruments than other variables examined.

Divisions: Life & Health Sciences > Optometry
Additional Information: If you have discovered material in Aston Research Explorer which is unlawful e.g. breaches copyright, (either yours or that of a third party) or any other law, including but not limited to those relating to patent, trademark, confidentiality, data protection, obscenity, defamation, libel, then please read our Takedown Policy and contact the service immediately.
Institution: Aston University
Uncontrolled Keywords: intraocular pressure,disposable contact lenses,modulus of elasticity,rebound tonometry,ocular response analyser
Completed Date: 2016-10-19
Authors: Booysen, Dirk


Export / Share Citation


Additional statistics for this record