Regulation of G protein-coupled receptors by palmitoylation and cholesterol


Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.See research article

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Divisions: Life & Health Sciences
Additional Information: © 2012 Goddard and Watts; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: Physiology,Biotechnology,Structural Biology,Developmental Biology,Plant Science,Ecology, Evolution, Behavior and Systematics,Cell Biology,Biochemistry, Genetics and Molecular Biology(all),Agricultural and Biological Sciences(all)
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Comment/Debate
Published Date: 2012-03-19
Accepted Date: 2012-03-01
Submitted Date: 2012-03-01
Authors: Goddard, Alan D. ( 0000-0003-4950-7470)
Watts, Anthony



Version: Published Version

License: Creative Commons Attribution

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