A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS

Schwarz, Konstantin, Singh, Satnam, Parasuraman, Satish Kumar, Bruce, Maggie, Shepstone, Lee, Feelisch, Martin, Minnion, Magdalena, Ahmad, Shakil, Horowitz, John, Dawson, Dana K. and Frenneaux, Michael P. (2016). A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS. Future Cardiology, 12 (6), pp. 617-626.

Abstract

In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.

Publication DOI: https://doi.org/10.2217/fca-2016-0026
Divisions: Aston Medical School
Uncontrolled Keywords: angina,Inorganic nitrate,randomized controlled trial,Molecular Medicine,Cardiology and Cardiovascular Medicine
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.futu ... 7/fca-2016-0026 (Publisher URL)
Published Date: 2016-11
Published Online Date: 2016-10-12
Authors: Schwarz, Konstantin
Singh, Satnam
Parasuraman, Satish Kumar
Bruce, Maggie
Shepstone, Lee
Feelisch, Martin
Minnion, Magdalena
Ahmad, Shakil ( 0000-0002-9294-0475)
Horowitz, John
Dawson, Dana K.
Frenneaux, Michael P.

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