Optical redox ratio and endogenous porphyrins in the detection of urinary bladder cancer:a patient biopsy analysis

Palmer, Scott, Litvinova, Karina, Dunaev, Andrey, Yubo, Ji, McGloin, David and Nabi, Ghulam (2017). Optical redox ratio and endogenous porphyrins in the detection of urinary bladder cancer:a patient biopsy analysis. Journal of Biophotonics, 10 (8), pp. 1062-1073.


Bladder cancer is among the most common cancers in the UK and conventional detection techniques suffer from low sensitivity, low specificity, or both. Recent attempts to address the disparity have led to progress in the field of autofluorescence as a means to diagnose the disease with high efficiency, however there is still a lot not known about autofluorescence profiles in the disease. The multi-functional diagnostic system "LAKK-M" was used to assess autofluorescence profiles of healthy and cancerous bladder tissue to identify novel biomarkers of the disease. Statistically significant differences were observed in the optical redox ratio (a measure of tissue metabolic activity), the amplitude of endogenous porphyrins and the NADH/porphyrin ratio between tissue types. These findings could advance understanding of bladder cancer and aid in the development of new techniques for detection and surveillance.

Publication DOI: https://doi.org/10.1002/jbio.201600162
Divisions: Engineering & Applied Sciences
Additional Information: Funding: EU FP7 [project “ABLADE: Advanced bladder cancer diagnosis and therapy” (324370)]; NHS; and EPSRC (EP/K503010/1). Full datasets supporting this publication can be found at the following DOI: 10.15132/10000115.
Uncontrolled Keywords: autofluorescence,cancer biomarkers,detection,multifunctional laser,transitional cell carcinoma,urinary bladder cancer,Chemistry(all),Materials Science(all),Biochemistry, Genetics and Molecular Biology(all),Engineering(all),Physics and Astronomy(all)
Full Text Link: http://discover ... 22ccd636b).html
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2017-08
Authors: Palmer, Scott
Litvinova, Karina
Dunaev, Andrey
Yubo, Ji
McGloin, David
Nabi, Ghulam

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