Association of anticholinergic burden with adverse effects in older people with intellectual disabilities:an observational cross-sectional study

O'Dwyer, Máire, Maidment, Ian D., Bennett, Kathleen, Peklar, Jure, Mulryan, Niamh, McCallion, Philip, McCarron, Mary and Henman, Martin C. (2016). Association of anticholinergic burden with adverse effects in older people with intellectual disabilities:an observational cross-sectional study. British Journal of Psychiatry, 209 (6), pp. 504-510.

Abstract

BACKGROUND: No studies to date have investigated cumulative anticholinergic exposure and its effects in adults with intellectual disabilities. AIMS: To determine the cumulative exposure to anticholinergics and the factors associated with high exposure. METHOD: A modified Anticholinergic Cognitive Burden (ACB) scale score was calculated for a representative cohort of 736 people over 40 years old with intellectual disabilities, and associations with demographic and clinical factors assessed. RESULTS: Age over 65 years was associated with higher exposure (ACB 1-4 odds ratio (OR) = 3.28, 95% CI 1.49-7.28, ACB 5+ OR = 3.08, 95% CI 1.20-7.63), as was a mental health condition (ACB 1-4 OR = 9.79, 95% CI 5.63-17.02, ACB 5+ OR = 23.74, 95% CI 12.29-45.83). Daytime drowsiness was associated with higher ACB (P<0.001) and chronic constipation reported more frequently (26.6% ACB 5+ v. 7.5% ACB 0, P<0.001). CONCLUSIONS: Older people with intellectual disabilities and with mental health conditions were exposed to high anticholinergic burden. This was associated with daytime dozing and constipation.

Publication DOI: https://doi.org/10.1192/bjp.bp.115.173971
Divisions: Life & Health Sciences
Life & Health Sciences > Pharmacy
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences > Applied Health Research Group
Additional Information: This is an author-produced electronic version of an article accepted for publication in the British Journal of Psychiatry. The definitive publisher-authenticated version is available online at http://bjp.rcpsych.org
Uncontrolled Keywords: Psychiatry and Mental health
Full Text Link: http://bjp.rcps ... p.bp.115.173971
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2016-12-01
Authors: O'Dwyer, Máire
Maidment, Ian D. ( 0000-0003-4152-9704)
Bennett, Kathleen
Peklar, Jure
Mulryan, Niamh
McCallion, Philip
McCarron, Mary
Henman, Martin C.

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