Oxygen tension, H2S, and NO bioavailability:is there an interaction?

Kolluru, Gopi K., Prasai, Priya K., Kaskas, Amir M., Letchuman, Vijay and Pattillo, Christopher B. (2016). Oxygen tension, H2S, and NO bioavailability:is there an interaction? Journal of Applied Physiology, 120 (2), pp. 263-270.


Molecular oxygen (O2) is an essential component for survival and development. Variation in O2 levels leads to changes in molecular signaling and ultimately affects the physiological functions of many organisms. Nitric oxide (NO) and hydrogen sulfide (H2S) are two gaseous cellular signaling molecules that play key roles in several physiological functions involved in maintaining vascular homeostasis including vasodilation, anti-inflammation, and vascular growth. Apart from the aforementioned functions, NO and H2S are believed to mediate hypoxic responses and serve as O2 chemosensors in biological systems. In this literature review, we briefly discuss NO and H2S and their roles during hypoxia.

Publication DOI: https://doi.org/10.1152/japplphysiol.00365.2015
Divisions: Aston Medical School
Additional Information: Copyright © 2016 the American Physiological Society.
Full Text Link: http://jap.phys ... ntent/120/2/263
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Published Date: 2016-01-15
Authors: Kolluru, Gopi K. ( 0000-0002-6774-2020)
Prasai, Priya K.
Kaskas, Amir M.
Letchuman, Vijay
Pattillo, Christopher B.



Version: Published Version

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