Author response: can vascular function be assessed by the interpretation of retinal vascular diameter changes?

Heitmar, Rebekka, Blann, Andrew, Cubbidge, Robert Peter, Lip, Gregory and Gherghel, Doina (2011). Author response: can vascular function be assessed by the interpretation of retinal vascular diameter changes? Investigative Ophthalmology and Visual Science, 52 (1), pp. 636-638.

Abstract

A protocol with repeated stimulation cycles should be analyzed stepwise, in that each stimulation is evaluated, and a reaction pattern is identified. No two subjects will react identically, in that dilation and recovery times can vary; however, this is not reason enough to abandon a multiple stimulation cycle with fixed recovery and stimulation times. Furthermore, it enables us to examine and determine the range in which a normal subject will be placed and can then be compared to different pathophysiological states (i.e., smokers and different diseases). The purpose of our paper was to highlight the importance of evaluating these different cycles and the danger of false interpretation when averaging results. There are many different ways of evaluating dilatory responses and elasticity, but each of them must be carefully evaluated and should not be overaveraged, which can result in a loss of sensitivity and specificity.

Publication DOI: https://doi.org/10.1167/iovs.10-6690
Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Life & Health Sciences > Vision, Hearing and Language
Additional Information: Creative Commons Attribution Non-Commercial No Derivatives
Uncontrolled Keywords: Ophthalmology,Sensory Systems,Cellular and Molecular Neuroscience
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://iovs.arv ... ticleid=2128212 (Publisher URL)
Published Date: 2011-01
Authors: Heitmar, Rebekka ( 0000-0002-7657-1788)
Blann, Andrew
Cubbidge, Robert Peter
Lip, Gregory
Gherghel, Doina ( 0000-0001-9439-5573)

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