The amyloid precursor protein (APP) binds the PIKfyve complex and modulates its function

Currinn, Heather and Wassmer, Thomas (2016). The amyloid precursor protein (APP) binds the PIKfyve complex and modulates its function. Biochemical Society Transactions, 44 (1), pp. 185-190.


Phosphoinositides are important components of eukaryotic membranes that are required for multiple forms of membrane dynamics. Phosphoinositides are involved in defining membrane identity, mediate cell signalling and control membrane trafficking events. Due to their pivotal role in membrane dynamics, phosphoinositide de-regulation contributes to various human diseases. In this review, we will focus on the newly emerging regulation of the PIKfyve complex, a phosphoinositide kinase that converts the endosomal phosphatidylinositol-3-phosphate [PI(3)P] to phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2)], a low abundance phosphoinositide of outstanding importance for neuronal integrity and function. Loss of PIKfyve function is well known to result in neurodegeneration in both mousemodels and human patients. Our recent work has surprisingly identified the amyloid precursor protein (APP), the central molecule in Alzheimer s disease aetiology, as a novel interaction partner of a subunit of the PIKfyve complex, Vac14. Furthermore, it has been shown that APP modulates PIKfyve function and PI(3,5)P2 dynamics, suggesting that the APP gene family functions as regulator of PI(3,5)P2 metabolism. The recent advances discussed in this review suggest a novel, unexpected, â-amyloid-independent mechanism for neurodegeneration in Alzheimer s disease.

Publication DOI:
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences
Life & Health Sciences > Cellular and Molecular Biomedicine
Additional Information: © 2016 Authors; published by Portland Press Limited Funding: BBSRC [BB/K014862/1]
Uncontrolled Keywords: Alzheimer s disease,amyloid precursor protein,Fab1,phosphatidylinositol-3,5-bisphosphate,PIKfyve,trafficking,Vac14,Biochemistry
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.bioc ... ontent/44/1/185 (Publisher URL)
Published Date: 2016-02-15
Authors: Currinn, Heather
Wassmer, Thomas



Version: Accepted Version

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