Hebbian and homeostatic plasticity mechanisms in regular spiking and intrinsic bursting cells of cortical layer 5

Greenhill, Stuart David, Ranson, Adam and Fox, Kevin (2015). Hebbian and homeostatic plasticity mechanisms in regular spiking and intrinsic bursting cells of cortical layer 5. Neuron, 88 (3), pp. 539-552.

Abstract

Layer 5 contains the major projection neurons of the neocortex and is composed of two major cell types: regular spiking (RS) cells, which have cortico-cortical projections, and intrinsic bursting cells (IB), which have subcortical projections. Little is known about the plasticity processes and specifically the molecular mechanisms by which these two cell classes develop and maintain their unique integrative properties. In this study, we find that RS and IB cells show fundementally different experience-dependent plasticity processes and integrate Hebbian and homeostatic components of plasticity differently. Both RS and IB cells showed TNFα-dependent homeostatic plasticity in response to sensory deprivation, but IB cells were capable of a much faster synaptic depression and homeostatic rebound than RS cells. Only IB cells showed input-specific potentiation that depended on CaMKII autophosphorylation. Our findings demonstrate that plasticity mechanisms are not uniform within the neocortex, even within a cortical layer, but are specialized within subcircuits.

Publication DOI: https://doi.org/10.1016/j.neuron.2015.09.025
Divisions: Life & Health Sciences
Additional Information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Funding: MRC (G0901299 and MR/N003896/1) Supplementary data available at http://dx.doi.org/10.1016/j.neuron.2015.09.025
Uncontrolled Keywords: Neuroscience(all)
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2015-11-04
Authors: Greenhill, Stuart David ( 0000-0002-5038-5258)
Ranson, Adam
Fox, Kevin

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