Characterisation and surface-profiling techniques for composite particles produced by dry powder coating in pharmaceutical drug delivery

Dahmash, Eman Z. and Mohammed, Afzal R. (2016). Characterisation and surface-profiling techniques for composite particles produced by dry powder coating in pharmaceutical drug delivery. Drug Discovery Today, 21 (4), pp. 550-561.

Abstract

The production of composite particles using dry powder coating is a one-step, environmentally friendly, process for the fabrication of particles with targeted properties and favourable functionalities. Diverse functionalities, such flowability enhancement, content uniformity, and dissolution, can be developed from dry particle coating. In this review, we discuss the particle functionalities that can be tailored and the selection of characterisation techniques relevant to understanding their molecular basis. We address key features in the powder blend sampling process and explore the relevant characterisation techniques, focussing on the functionality delivered by dry coating and on surface profiling that explores the dynamics and surface characteristics of the composite blends. Dry particle coating is a solvent- and heat-free process that can be used to develop functionalised particles. However, assessment of the resultant functionality requires careful selection of sensitive analytical techniques that can distinguish particle surface changes within nano and/or micrometre ranges.

Publication DOI: https://doi.org/10.1016/j.drudis.2015.11.013
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences > Applied Health Research Group
Additional Information: © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords: Drug Discovery,Pharmacology
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2016-04
Authors: Dahmash, Eman Z.
Mohammed, Afzal R. ( 0000-0002-5212-3040)

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