Redox control of protein degradation

Pajares, Marta, Jiménez-Moreno, Natalia, Dias, Irundika H.K., Debelec, Bilge, Vucetic, Milica, Fladmark, Kari E., Basaga, Huveyda, Ribaric, Samo, Milisav, Irina and Cuadrado, Antonio (2015). Redox control of protein degradation. Redox biology, 6 , pp. 409-420.

Abstract

Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protein modification, as well as the impact of reactive oxygen species on the proteolytic systems that regulate cell response to an oxidant environment: the ubiquitin-proteasome system (UPS), autophagy and the unfolded protein response (UPR). In the presence of an oxidant environment, these systems are critical to ensure proteostasis and cell survival. An example of altered degradation of oxidized proteins in pathology is provided for neurodegenerative diseases. Future work will determine if protein oxidation is a valid target to combat proteinopathies.

Publication DOI: https://doi.org/10.1016/j.redox.2015.07.003
Divisions: Life & Health Sciences
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences > Psychology
Life & Health Sciences > Cell & Tissue Biomedical Research
Additional Information: © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Funding: European Cooperation in Science and Technology (COSTAction BM1203/EU-ROS); and Kidney Research UK (PDF3/2014).
Uncontrolled Keywords: protein degradation,reactive oxygen species,Biochemistry,Organic Chemistry
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2015-12
Authors: Pajares, Marta
Jiménez-Moreno, Natalia
Dias, Irundika H.K. ( 0000-0002-6620-8221)
Debelec, Bilge
Vucetic, Milica
Fladmark, Kari E.
Basaga, Huveyda
Ribaric, Samo
Milisav, Irina
Cuadrado, Antonio

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License: Creative Commons Attribution


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