Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay?

Sakel, M., Boukouvalas, A., Buono, R., Moten, M., Mirza, F., Chan, W.-Y., Maidment, I., Cross, J., Smith, T.O., Myint, P.K. and Fox, C. (2015). Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay? Brain Injury, 29 (12), pp. 1426-1430.

Abstract

Primary objective: To assess the relationship between disability, length of stay (LOS) and anticholinergic burden (ACB) with people following acquired brain or spinal cord injury. Research design: A retrospective case note review assessed total rehabilitation unit admission. Methods and procedures: Assessment of 52 consecutive patients with acquired brain/spinal injury and neuropathy in an in-patient neuro-rehabilitation unit of a UK university hospital. Data analysed included: Northwick Park Dependency Score (NPDS), Rehabilitation complexity Scale (RCS), Functional Independence Measure and Functional Assessment Measure FIM-FAM (UK version 2.2), LOS and ACB. Outcome was different in RCS, NPDS and FIM-FAM between admission and discharge. Main outcomes and results: A positive change was reported in ACB results in a positive change in NPDS, with no significant effect on FIM-FAM, either Motor or Cognitive, or on the RCS. Change in ACB correlated to the length of hospital stay (regression correlation = −6.64; SE = 3.89). There was a significant harmful impact of increase in ACB score during hospital stay, from low to high ACB on NPDS (OR = 9.65; 95% CI = 1.36–68.64) and FIM-FAM Total scores (OR = 0.03; 95% CI = 0.002–0.35). Conclusions: There was a statistically significant correlation of ACB and neuro-disability measures and LOS amongst this patient cohort.

Publication DOI: https://doi.org/10.3109/02699052.2015.1060358
Divisions: Engineering & Applied Sciences > Computer science
Life & Health Sciences
Life & Health Sciences > Pharmacy
Life & Health Sciences > Applied Health Research Group
Uncontrolled Keywords: adverse event,Anticholingeric,function,length of stay,rehabilitation unit,spinal cord,traumatic brain injury,Clinical Neurology,Arts and Humanities (miscellaneous),Developmental and Educational Psychology
Full Text Link: http://informah ... 52.2015.1060358
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2015
Authors: Sakel, M.
Boukouvalas, A.
Buono, R.
Moten, M.
Mirza, F.
Chan, W.-Y.
Maidment, I. ( 0000-0003-4152-9704)
Cross, J.
Smith, T.O.
Myint, P.K.
Fox, C.

Download

[img]

Version: Accepted Version


Export / Share Citation


Statistics

Additional statistics for this record