Copper complexes as a source of redox active MRI contrast agents

Abstract

The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.

Publication DOI: https://doi.org/10.1007/s10534-015-9875-3
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences
Life & Health Sciences > Chronic and Communicable Conditions
Additional Information: The final publication is available at Springer via http://dx.doi.org/10.1007/s10534-015-9875-3 Funding: BBSRC (BBS/B/01553). Electronic supplementary material (doi: 10.1007/s10534-015-9875-3).
Uncontrolled Keywords: copper macrocycles,oxidation–reduction,Redox sensitive contrast agent,imaging,inflammation,Biomaterials,Metals and Alloys,Agricultural and Biological Sciences(all),Biochemistry, Genetics and Molecular Biology(all)
Full Text Link: http://link.spr ... 0534-015-9875-3
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2015
Published Online Date: 2015-08-09
Authors: Dunbar, Lynsey
Sowden, Rebecca J.
Trotter, Katherine D.
Taylor, Michelle K.
Smith, David
Kennedy, Alan R.
Reglinski, John
Spickett, Corinne M. ( 0000-0003-4054-9279)

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Version: Accepted Version


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