Insulin therapy in people with type 2 diabetes:opportunities and challenges?

Home, Philip, Riddle, Matthew, Cefalu, William T., Bailey, Clifford J., Bretzel, Reinhard G., del Prato, Stefano, Leroith, Derek, Schernthaner, Guntram, van Gaal, Luc and Raz, Itamar (2014). Insulin therapy in people with type 2 diabetes:opportunities and challenges? Diabetes Care, 37 (6), pp. 1499-1508.

Abstract

Given the continued interest in defining the optimal management of individuals with type 2 diabetes, the Editor of Diabetes Care convened a working party of diabetes specialists to examine this topic in the context of insulin therapy. This was prompted by recent new evidence on the use of insulin in such people. The group was aware of evidence that the benefits of insulin therapy are still usually offered late, and thus the aim of the discussion was how to define the optimal timing and basis for decisions regarding insulin and to apply these concepts in practice. It was noted that recent evidence had built upon that of the previous decades, together confirming the benefits and safety of insulin therapy, albeit with concerns about the potential for hypoglycemia and gain in body weight. Insulin offers a unique ability to control hyperglycemia, being used from the time of diagnosis in some circumstances, when metabolic control is disturbed by medical illness, procedures, or therapy, as well as in the longer term in ambulatory care. For those previously starting insulin, various other forms of therapy can be added later, which offer complementary effects appropriate to individual needs. Here we review current evidence and circumstances in which insulin can be used, consider individualized choices of alternatives and combination regimens, and offer some guidance on personalized targets and tactics for glycemic control in type 2 diabetes.

Publication DOI: https://doi.org/10.2337/dc13-2743
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences
Life & Health Sciences > Cell & Tissue Biomedical Research
Additional Information: Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
Uncontrolled Keywords: Internal Medicine,Endocrinology, Diabetes and Metabolism,Advanced and Specialised Nursing,Medicine(all)
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2014-06
Authors: Home, Philip
Riddle, Matthew
Cefalu, William T.
Bailey, Clifford J. ( 0000-0002-6998-6811)
Bretzel, Reinhard G.
del Prato, Stefano
Leroith, Derek
Schernthaner, Guntram
van Gaal, Luc
Raz, Itamar

Download

Export / Share Citation


Statistics

Additional statistics for this record