Thiol redox homeostasis in neurodegenerative disease


This review provides an overview of the biochemistry of thiol redox couples and the significance of thiol redox homeostasis in neurodegenerative disease. The discussion is centred on cysteine/cystine redox balance, the significance of the xc- cystine-glutamate exchanger and the association between protein thiol redox balance and neurodegeneration, with particular reference to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and glaucoma. The role of thiol disulphide oxidoreductases in providing neuroprotection is also discussed.

Publication DOI:
Divisions: Life & Health Sciences
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences > Cell & Tissue Biomedical Research
Additional Information: © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license ( Supported by the European Cooperation In Science and Technology (COST) Action BM1203, EU-ROS.
Uncontrolled Keywords: cysteine,glutathione,thioredoxin,glutaredoxin,peroxiredoxin,neurodegenerative disease,Biochemistry,Organic Chemistry
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2015-08
Published Online Date: 2015-04-22
Authors: McBean, Gethin J.
Aslan, Mutay
Griffiths, Helen R. ( 0000-0002-2666-2147)
Torrão, Rita C

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