An in-vitro-in-vivo model for the transdermal delivery of cholecalciferol for the purposes of rodent management

Davies, J. and Ingham, A. (2015). An in-vitro-in-vivo model for the transdermal delivery of cholecalciferol for the purposes of rodent management. International Journal of Pharmaceutics, 487 (1-2), pp. 101-109.

Abstract

The natural selection of anticoagulant resistant rats has resulted in a need for an alternative to anticoagulant rodenticides which differs in both active ingredient and in the method of dosing. Cholecalciferol toxicity to rodents using the dermal route is demonstrated using a variety of penetration enhancing formulations in two in-vitro models and finally in-vivo. A 1 ml dose of 50/50 (v/v) DMSO/ethanol containing 15% (v/v) PEG 200 and 20% (w/v) cholecalciferol was judged as 'sufficiently effective' in line with the European Union's Biocidal Products Regulation (No. 528/2012) during in-vivo studies. This dose was found to cause 100% mortality in a rat population in 64.4 h (±22 h).

Publication DOI: https://doi.org/10.1016/j.ijpharm.2015.03.055
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences > Applied Health Research Group
Additional Information: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0). Funding: European Union’s Seventh Framework Programme managed by REA Research Executive Agency http://ec.europa.eu/rea (FP7/2007-2013) under grant Project Reference 286852.
Uncontrolled Keywords: BPR,cholecalciferol,efficacy,regulation No. 528/2012,transdermal,rodenticide,Pharmaceutical Science
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2015-06-20
Authors: Davies, J.
Ingham, A.

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