MARK-AGE biomarkers of ageing

Abstract

Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

Publication DOI: https://doi.org/10.1016/j.mad.2015.03.006
Divisions: Life & Health Sciences
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences > Cell & Tissue Biomedical Research
Additional Information: © 2015 Z. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). European Commission for financial support through the FP7 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; grant agreement no.: 200880.
Uncontrolled Keywords: ageing biomarkers,human studies,MARK-AGE,Ageing,Developmental Biology
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2015-11
Published Online Date: 2015-03-24
Authors: Bürkle, Alexander
Moreno-Villanueva, María
Bernhard, Jürgen
Blasco, María
Zondag, Gerben
Hoeijmakers, Jan H.J.
Toussaint, Olivier
Grubeck-Loebenstein, Beatrix
Mocchegiani, Eugenio
Collino, Sebastiano
Gonos, Efstathios S.
Sikora, Ewa
Gradinaru, Daniela
Dollé, Martijn
Salmon, Michel
Kristensen, Peter
Griffiths, Helen R. ( 0000-0002-2666-2147)
Libert, Claude
Grune, Tilman
Breusing, Nicolle
Simm, Andreas
Franceschi, Claudio
Capri, Miriam
Talbot, Duncan
Caiafa, Paola
Friguet, Bertrand
Slagboom, P. Eline
Hervonen, Antti
Hurme, Mikko
Aspinall, Richard

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