MARK-AGE biomarkers of ageing

Bürkle, Alexander, Moreno-Villanueva, María, Bernhard, Jürgen, Blasco, María, Zondag, Gerben, Hoeijmakers, Jan H.J., Toussaint, Olivier, Grubeck-Loebenstein, Beatrix, Mocchegiani, Eugenio, Collino, Sebastiano, Gonos, Efstathios S., Sikora, Ewa, Gradinaru, Daniela, Dollé, Martijn, Salmon, Michel, Kristensen, Peter, Griffiths, Helen R., Libert, Claude, Grune, Tilman, Breusing, Nicolle, Simm, Andreas, Franceschi, Claudio, Capri, Miriam, Talbot, Duncan, Caiafa, Paola, Friguet, Bertrand, Slagboom, P. Eline, Hervonen, Antti, Hurme, Mikko and Aspinall, Richard (2015). MARK-AGE biomarkers of ageing. Mechanisms of Ageing and Development, 151 , pp. 2-12.


Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

Publication DOI:
Divisions: Life & Health Sciences
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences > Cell & Tissue Biomedical Research
Additional Information: © 2015 Z. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license ( European Commission for financial support through the FP7 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; grant agreement no.: 200880.
Uncontrolled Keywords: ageing biomarkers,human studies,MARK-AGE,Ageing,Developmental Biology
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2015-11
Authors: Bürkle, Alexander
Moreno-Villanueva, María
Bernhard, Jürgen
Blasco, María
Zondag, Gerben
Hoeijmakers, Jan H.J.
Toussaint, Olivier
Grubeck-Loebenstein, Beatrix
Mocchegiani, Eugenio
Collino, Sebastiano
Gonos, Efstathios S.
Sikora, Ewa
Gradinaru, Daniela
Dollé, Martijn
Salmon, Michel
Kristensen, Peter
Griffiths, Helen R. ( 0000-0002-2666-2147)
Libert, Claude
Grune, Tilman
Breusing, Nicolle
Simm, Andreas
Franceschi, Claudio
Capri, Miriam
Talbot, Duncan
Caiafa, Paola
Friguet, Bertrand
Slagboom, P. Eline
Hervonen, Antti
Hurme, Mikko
Aspinall, Richard

Export / Share Citation


Additional statistics for this record