Recent advances in topical therapeutics for vitreoretinal diseases

Gibson, Jonathan and McGinnigle, Samantha (2015). Recent advances in topical therapeutics for vitreoretinal diseases. US Ophthalmic Review, 8 (1), pp. 2-7.


Eye drops are convenient for patients, but achieving therapeutic doses and maintaining sustained drug release without frequent re-application to treat diseases of the retina has been largely unsuccessful. Topical administration of drugs is hindered by the anatomy, physiology, and biochemistry of the eye and its highly effective defence mechanisms. Advances in nanotechnology have led to the experimental use of topical permeation-enhancing liposomes, emulsions, and microspheres to enhance absorption and penetration of drugs across membranes; allow controlled release of the drug; and to target drugs at distinct tissues to allow sufficient local bioavailability. In the near future it is hoped that improved technologies may provide means of sustained topical drug delivery for retinal therapy, with improved side-effect profiles and reduced cost compared with currently available clinical treatments.

Divisions: Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Life & Health Sciences > Vision, Hearing and Language
Life & Health Sciences > Optometry
Additional Information: This article is published under the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, adaptation, and reproduction provided the original author(s) and source are given appropriate credit.
Uncontrolled Keywords: nanoparticles,eye drops,diabetes,retinal disorders,topical ocular delivery,liposomes,Medicine(all)
Full Text Link: http://www.touc ... etinal-diseases
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Published Date: 2015
Authors: Gibson, Jonathan ( 0000-0002-9281-5244)
McGinnigle, Samantha



Version: Published Version

License: Creative Commons Attribution Non-commercial

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