PPD v1.0 - an integrated, web-accessible database of experimentally determined protein pKa values

Toseland, Christopher P., McSparron, Helen, Davies, Matthew N. and Flower, Darren R. (2006). PPD v1.0 - an integrated, web-accessible database of experimentally determined protein pKa values. Nucleic Acids Research, 34 (Suppl.), D199-D203.

Abstract

The Protein pKa Database (PPD) v1.0 provides a compendium of protein residue-specific ionization equilibria (pKa values), as collated from the primary literature, in the form of a web-accessible postgreSQL relational database. Ionizable residues play key roles in the molecular mechanisms that underlie many biological phenomena, including protein folding and enzyme catalysis. The PPD serves as a general protein pKa archive and as a source of data that allows for the development and improvement of pKa prediction systems. The database is accessed through an HTML interface, which offers two fast, efficient search methods: an amino acid-based query and a Basic Local Alignment Search Tool search. Entries also give details of experimental techniques and links to other key databases, such as National Center for Biotechnology Information and the Protein Data Bank, providing the user with considerable background information.

Publication DOI: https://doi.org/10.1093/nar/gkj035
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Additional Information: © The Author 2006. Published by Oxford University Press. All rights reserved The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org
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Related URLs: http://nar.oxfo ... 34/suppl_1/D199 (Publisher URL)
Published Date: 2006-01
Authors: Toseland, Christopher P.
McSparron, Helen
Davies, Matthew N.
Flower, Darren R. ( 0000-0002-8542-7067)

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