The influence of mouse Ped gene expression on postnatal development

Watkins, Adam, Wilkins, Adrian, Osmond, Clive, Warner, Carol M., Comiskey, Martina, Hanson, Mark and Fleming, Tom P. (2006). The influence of mouse Ped gene expression on postnatal development. Journal of Physiology, 571 , pp. 211-220.


The Ped (preimplantation embryo development) gene, whose product is Qa-2 protein, is correlated with a faster rate of preimplantation development (Ped fast phenotype) in mice that express Qa-2 protein compared with mice with an absence of Qa-2 protein (Ped slow phenotype). In the current study, we have used two congenic mouse strains differentially expressing the Ped gene, strain B6.K1 (Ped slow; Qa-2 negative) and strain B6.K2 (Ped fast; Qa-2 positive), to investigate the effects of Ped gene expression on postnatal growth profiles, systolic blood pressure and adult organ allometry. At birth, B6.K1 mice were moderately lighter than B6.K2 mice. B6.K1 mice became heavier during postnatal life (P

Publication DOI:
Divisions: Life & Health Sciences > Biosciences
Full Text Link: https://www.ncb ... les/PMC1805639/
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://jp.physo ... ntent/571/1/211 (Publisher URL)
Published Date: 2006-02-15
Authors: Watkins, Adam
Wilkins, Adrian
Osmond, Clive
Warner, Carol M.
Comiskey, Martina
Hanson, Mark
Fleming, Tom P.

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