The effect of simulated cataract light scatter on retinal vessel oximetry

Patel, Sunni R., Hudson, Chris, Flanagan, John G. and Heitmar, Rebekka (2013). The effect of simulated cataract light scatter on retinal vessel oximetry. Experimental Eye Research, 116 , pp. 185-189.

Abstract

To assess the impact of light scatter, similar to that introduced by cataract on retinal vessel blood oxygen saturation measurements using poly-bead solutions of varying concentrations. Eight healthy, young, non-smoking individuals were enrolled for this study. All subjects underwent digital blood pressure measurements, assessment of non-contact intraocular pressure, pupil dilation and retinal vessel oximetry using dual wavelength photography (Oximetry Module, Imedos Systems, Germany). To simulate light scatter, cells comprising a plastic collar and two plano lenses were filled with solutions of differing concentrations (0.001, 0.002 and 0.004%) of polystyrene microspheres (Polysciences Inc., USA). The adopted light scatter model showed an artifactual increase in venous optical density ratio (p=0.036), with the 0.004% condition producing significantly higher venous optical density ratio values when compared to images without a cell in place. Spectrophotometric analysis, and thus retinal vessel oximetry of the retinal vessels, is altered by artificial light scatter. © 2013 Elsevier Ltd.

Publication DOI: https://doi.org/10.1016/j.exer.2013.09.004
Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Life & Health Sciences > Vision, Hearing and Language
Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Experimental eye research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Patel, SR, Hudson, C, Flanagan, JG & Heitmar, R, 'The effect of simulated cataract light scatter on retinal vessel oximetry' Experimental eye research, vol. 116 (2013) DOI http://dx.doi.org/10.1016/j.exer.2013.09.004
Uncontrolled Keywords: cataract models,extraneous factors,light scatter,retinal oximetry,retinal oxygenation,Ophthalmology,Sensory Systems,Cellular and Molecular Neuroscience
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2013-11
Authors: Patel, Sunni R.
Hudson, Chris
Flanagan, John G.
Heitmar, Rebekka ( 0000-0002-7657-1788)

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