Effect of a tumour-derived lipid-mobilising factor on glucose and lipid metabolism in vivo

Russell, S.T. and Tisdale, M.J. (2002). Effect of a tumour-derived lipid-mobilising factor on glucose and lipid metabolism in vivo. British Journal of Cancer, 87 (5), pp. 580-584.


Treatment of ex-breeder male NMRI mice with lipid mobilising factor isolated from the urine of cachectic cancer patients, caused a significant increase in glucose oxidation to CO2, compared with control mice receiving phosphate buffered saline. Glucose utilisation by various tissues was determined by the 2-deoxyglucose tracer technique and shown to be elevated in brain, heart, brown adipose tissue and gastrocnemius muscle. The tissue glucose metabolic rate was increased almost three-fold in brain, accounting for the ability of lipid mobilising factor to decrease blood glucose levels. Lipid mobilising factor also increased overall lipid oxidation, as determined by the production of 14CO2 from [14C carboxy] triolein, being 67% greater than phosphate buffered saline controls over a 24 h period. There was a significant increase in [14C] lipid accumulation in plasma, liver and white and brown adipose tissue after administration of lipid mobilising factor. These results suggest that changes in carbohydrate metabolism and loss of adipose tissue, together with an increased whole body fatty acid oxidation in cachectic cancer patients, may arise from tumour production of lipid mobilising factor. © 2002 Cancer Research UK.

Publication DOI: https://doi.org/10.1038/sj.bjc.6600493
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Additional Information: © 2002 Cancer Research UK Creative Commons Attribution-NonCommercial-Share-Alike 3.0 licence, subject to the conditions listed at http://creativecommons.org/licences/by-nc-sa/3.0/
Uncontrolled Keywords: cachexia,glucose and lipid metabolism,lipid mobilising factor,Cancer Research,Oncology
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.natu ... l/6600493a.html (Publisher URL)
Published Date: 2002-08-27
Authors: Russell, S.T.
Tisdale, M.J.


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