Effect of catechol derivatives on cell growth and lipoxygenase activity

Simpson, Julie, Forrester, Rebecca, Tisdale, Michael J., Billington, David C. and Rathbone, Daniel L. (2003). Effect of catechol derivatives on cell growth and lipoxygenase activity. Bioorganic and Medicinal Chemistry Letters, 13 (15), pp. 2435-2439.


Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC 5010 -6-10 -7 M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC 50 ∼1 μM). © 2003 Elsevier Ltd. All rights reserved.

Publication DOI: https://doi.org/10.1016/S0960-894X(03)00528-6
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Uncontrolled Keywords: salicylic acid,lipoxygenase inhibitors,phenolic dihydroxy moiety,murine colonic tumour cells,inhibitors,catechols,Biochemistry,Molecular Biology,Organic Chemistry,Drug Discovery,Pharmaceutical Science
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2003-08-04
Authors: Simpson, Julie
Forrester, Rebecca
Tisdale, Michael J.
Billington, David C.
Rathbone, Daniel L. ( 0000-0003-4732-4662)


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