Solid phase synthesis of a metronidazole oligonucleotide conjugate

Walsh, Andrew J., Davis, Michael L. and Fraser, William (2006). Solid phase synthesis of a metronidazole oligonucleotide conjugate. Molecules, 11 (6), pp. 486-495.

Abstract

Direct, solid phase synthesis of an oligonucleotide conjugate of the antibiotic drug metronidazole was accomplished by the phosphoramidite method. Removal of protecting groups and cleavage from the controlled pore glass (CPG) solid support was successful using mild conditions (20% EtN in pyridine, then conc. NH (aq) at rt for 30 min) whereas standard conditions (conc. NH (aq) at 55°C for 16 h) cleaved the drug.

Publication DOI: https://doi.org/10.3390/11060486
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Additional Information: Creative commons : Attribution
Uncontrolled Keywords: CPG,conjugate,metronidazole,oligonucleotide,phosphoramidite,solid phase
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.mdpi ... 0-3049/11/6/486 (Publisher URL)
Published Date: 2006-06-23
Authors: Walsh, Andrew J.
Davis, Michael L.
Fraser, William ( 0000-0001-6588-0166)

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License: Creative Commons Attribution


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