A preliminary investigation into the effects of ocular lubricants on higher order aberrations in normal and dry eye subjects


Purpose: To study the effects of ocular lubricants on higher order aberrations in normal and self-diagnosed dry eyes. Methods: Unpreserved hypromellose drops, Tears Again™ liposome spray and a combination of both were administered to the right eye of 24 normal and 24 dry eye subjects following classification according to a 5 point questionnaire. Total ocular higher order aberrations, coma, spherical aberration and Strehl ratios for higher order aberrations were measured using the Nidek OPD-Scan III (Nidek Technologies, Gamagori, Japan) at baseline, immediately after application and after 60. min. The aberration data were analyzed over a 5. mm natural pupil using Zernike polynomials. Each intervention was assessed on a separate day and comfort levels were recorded before and after application. Corneal staining was assessed and product preference recorded after the final measurement for each intervention. Results: Hypromellose drops caused an increase in total higher order aberrations (p= <0.01 in normal and dry eyes) and a reduction in Strehl ratio (normal eyes: p= <0.01, dry eyes p= 0.01) immediately after instillation. There were no significant differences between normal and self-diagnosed dry eyes for response to intervention and no improvement in visual quality or reduction in higher order aberrations after 60. min. Differences in comfort levels failed to reach statistical significance. Conclusion: Combining treatments does not offer any benefit over individual treatments in self-diagnosed dry eyes and no individual intervention reached statistical significance. Symptomatic subjects with dry eye and no corneal staining reported an improvement in comfort after using lubricants. © 2013 British Contact Lens Association.

Publication DOI: https://doi.org/10.1016/j.clae.2013.08.156
Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Life & Health Sciences > Vision, Hearing and Language
Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Contact lens and anterior eye. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in McGinnigle, S, Eperjesi, F & Naroo, SA, 'A preliminary investigation into the effects of ocular lubricants on higher order aberrations in normal and dry eye subjects' Contact lens and anterior eye, Vol. 37, No. 2 (2014) DOI http://dx.doi.org/10.1016/j.clae.2013.08.156
Uncontrolled Keywords: dry eye,high order aberrations,lubricants,Ophthalmology,Optometry
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2014-04
Published Online Date: 2013-09-24
Authors: McGinnigle, Samantha
Eperjesi, Frank ( 0000-0003-4358-0095)
Naroo, Shehzad A. ( 0000-0002-6373-7187)



Version: Accepted Version

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