Impact of soft contact lens edge design and mid-peripheral lens shape on the epithelium and its indentation with lens mobility

Wolffsohn, James, Drew, Thomas, Dhallu, Sandeep, Sheppard, Amy, Hofmann, Greg J. and Prince, Mark (2013). Impact of soft contact lens edge design and mid-peripheral lens shape on the epithelium and its indentation with lens mobility. Investigative Ophthalmology and Visual Science, 54 (9), pp. 6190-6196.

Abstract

Purpose. To evaluate the influence of soft contact lens midperipheral shape profile and edge design on the apparent epithelial thickness and indentation of the ocular surface with lens movement. Methods. Four soft contact lens designs comprising of two different plano midperipheral shape profiles and two edge designs (chiseled and knife edge) of silicone-hydrogel material were examined in 26 subjects aged 24.7 ± 4.6 years, each worn bilaterally in randomized order. Lens movement was imaged enface on insertion, at 2 and 4 hours with a high-speed, high-resolution camera simultaneous to the cross-section of the edge of the contact lens interaction with the ocular surface captured using optical coherence tomography (OCT) nasally, temporally, and inferiorly. Optical imaging distortions were individually corrected for by imaging the apparent distortion of a glass slide surface by the removed lens. Results. Apparent epithelial thickness varied with edge position (P < 0.001). When distortion was corrected for, epithelial indentation decreased with time after insertion (P = 0.010), changed after a blink (P < 0.001), and varied with position on the lens edge (P < 0.001), with the latter being affected by midperipheral lens shape profile and edge design. Horizontal and vertical lens movement did not change with time postinsertion. Vertical motion was affected by midperipheral lens shape profile (P < 0.001) and edge design (P < 0.001). Lens movement was associated with physiologic epithelium thickness for lens midperipheral shape profile and edge designs. Conclusions. Dynamic OCT coupled with high-resolution video demonstrated that soft contact lens movement and image-corrected ocular surface indentation were influenced by both lens edge design and midperipheral lens shape profiles.

Publication DOI: https://doi.org/10.1167/iovs.13-12425
Divisions: Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Life & Health Sciences > Vision, Hearing and Language
Life & Health Sciences > Optometry
Engineering & Applied Sciences
Engineering & Applied Sciences > Mechanical Engineering & Design
Additional Information: Copyright 2013 The Association for Research in Vision and Ophthalmology, Inc. Creative Commons Attribution Non-Commercial No Derivatives License
Uncontrolled Keywords: contact lenses,edge design,epithelial indentation,epithelial thickness,Ophthalmology,Sensory Systems,Cellular and Molecular Neuroscience,Medicine(all)
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://iovs.arv ... ticleid=2127908 (Publisher URL)
Published Date: 2013-09-18
Authors: Wolffsohn, James ( 0000-0003-4673-8927)
Drew, Thomas
Dhallu, Sandeep
Sheppard, Amy ( 0000-0003-0035-8267)
Hofmann, Greg J.
Prince, Mark ( 0000-0002-3709-099X)

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