High speed DSC (hyper-DSC) as a tool to measure the solubility of a drug within a solid or semi-solid matrix


Conventional differential scanning calorimetry (DSC) techniques are commonly used to quantify the solubility of drugs within polymeric-controlled delivery systems. However, the nature of the DSC experiment, and in particular the relatively slow heating rates employed, limit its use to the measurement of drug solubility at the drug's melting temperature. Here, we describe the application of hyper-DSC (HDSC), a variant of DSC involving extremely rapid heating rates, to the calculation of the solubility of a model drug, metronidazole, in silicone elastomer, and demonstrate that the faster heating rates permit the solubility to be calculated under non-equilibrium conditions such that the solubility better approximates that at the temperature of use. At a heating rate of 400°C/min (HDSC), metronidazole solubility was calculated to be 2.16 mg/g compared with 6.16 mg/g at 20°C/min. © 2005 Elsevier B.V. All rights reserved.

Publication DOI: https://doi.org/10.1016/j.ijpharm.2005.04.038
Divisions: Life & Health Sciences > Pharmacy
Uncontrolled Keywords: high-speed DSC,metronidazole,silicone,solubility,Pharmaceutical Science
Full Text Link: https://pure.qu ... amaglia2005.pdf
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2005-09
Authors: Gramaglia, Daniela
Conway, Barbara R.
Kett, Vicky L.
Malcolm, R. Karl
Batchelor, Hannah K.

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