Suitability of dysphonia measurements for telemonitoring of Parkinson's disease

Little, Max A., McSharry, Patrick E., Hunter, Eric J., Spielman, Jennifer and Ramig, Lorraine O. (2009). Suitability of dysphonia measurements for telemonitoring of Parkinson's disease. IEEE Transactions on Biomedical Engineering, 56 (4), pp. 1015-1022.

Abstract

We present an assessment of the practical value of existing traditional and non-standard measures for discriminating healthy people from people with Parkinson's disease (PD) by detecting dysphonia. We introduce a new measure of dysphonia, Pitch Period Entropy (PPE), which is robust to many uncontrollable confounding effects including noisy acoustic environments and normal, healthy variations in voice frequency. We collected sustained phonations from 31 people, 23 with PD. We then selected 10 highly uncorrelated measures, and an exhaustive search of all possible combinations of these measures finds four that in combination lead to overall correct classification performance of 91.4%, using a kernel support vector machine. In conclusion, we find that non-standard methods in combination with traditional harmonics-to-noise ratios are best able to separate healthy from PD subjects. The selected non-standard methods are robust to many uncontrollable variations in acoustic environment and individual subjects, and are thus well-suited to telemonitoring applications.

Publication DOI: https://doi.org/10.1109/TBME.2008.2005954
Divisions: Engineering & Applied Sciences > Mathematics
Additional Information: © 2009 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Uncontrolled Keywords: biomedical measurements,nervous system,speech analysis,telemedicine,Biomedical Engineering
Full Text Link: http://ieeexplo ... rnumber=4636708
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2009-04
Authors: Little, Max A. ( 0000-0002-1507-3822)
McSharry, Patrick E.
Hunter, Eric J.
Spielman, Jennifer
Ramig, Lorraine O.

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