Initiation and progression of ossification of the posterior longitudinal ligament of the cervical spine in the hereditary spinal hyperostotic mouse (twy/twy)


Ossification of the posterior longitudinal ligament (OPLL) is a significantly critical pathology that can eventually cause serious myelopathy. Ossification commences in the vertebral posterior longitudinal ligaments, and intensifies and spreads with the progression of the disease, resulting in osseous projections and compression of the spinal cord. However, the paucity of histological studies the underlying mechanisms of calcification and ossification processes remain obscure. The pathological process could be simulated in the ossifying process of the ligament in mutant spinal hyperostotic mouse (twy/twy). The aim of this study is to observe that enlargement of the nucleus pulposus followed by herniation, disruption and regenerative proliferation of annulus fibrosus cartilaginous tissues participated in the initiation of ossification of the posterior longitudinal ligament of twy/twy mice.

Publication DOI:
Divisions: Life & Health Sciences
Life & Health Sciences > Cellular and Molecular Biomedicine
Life & Health Sciences > Biosciences
Additional Information: Creative Commons Attribution Licence. © The Author(s) 2011. This article is published with open access at
Uncontrolled Keywords: ossification of the posterior longitudinal ligament,twy/twy mouse,nucleus pulposus herniation,annulus fibrosus,enchondral ossification,Surgery,Orthopedics and Sports Medicine
Full Text Link: http://10.1007/ ... 0586-011-1971-7
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2012-01
Published Online Date: 2011-08-18
Authors: Uchida, Kenzo
Yayama, Takafumi
Sugita, Daisuke
Nakajima, Hideaki
Guerrero, Alexander R.
Watanabe, Shuji
Roberts, Sally
Johnson, William E.
Baba, Hisatoshi



Version: Published Version

License: Creative Commons Attribution

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