Discriminating antigen and non-antigen using proteome dissimilarity:bacterial antigens

Ramakrishnan, Kamna and Flower, Darren R (2010). Discriminating antigen and non-antigen using proteome dissimilarity:bacterial antigens. Bioinformation, 4 (10), pp. 445-7.


It has been postulated that immunogenicity results from the overall dissimilarity of pathogenic proteins versus the host proteome. We have sought to use this concept to discriminate between antigens and non-antigens of bacterial origin. Sets of 100 known antigenic and nonantigenic peptide sequences from bacteria were compared to human and mouse proteomes. Both antigenic and non-antigenic sequences lacked human or mouse homologues. Observed distributions were compared using the non-parametric Mann-Whitney test. The statistical null hypothesis was accepted, indicating that antigen and non-antigens did not differ significantly. Likewise, we were unable to determine a threshold able to separate meaningfully antigen from non-antigen. Thus, antigens cannot be predicted from pathogen genomes based solely on their dissimilarity to the human genome.

Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Additional Information: This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
Uncontrolled Keywords: antigen,non-antigen,proteome,dissimilarity,bacterial antigens
Published Date: 2010-04-30
Authors: Ramakrishnan, Kamna
Flower, Darren R ( 0000-0002-8542-7067)



Version: Published Version

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