The case for aluminium as the neurotoxin in sporadic Alzheimer's disease

Hodgkins, Paul S., Blair, J.A. and Armstrong, Richard A. (1993). The case for aluminium as the neurotoxin in sporadic Alzheimer's disease. IN: 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines. 1993-02-01. (Unpublished)

Abstract

The flash-pattern evoked potential difference (F - P) in man increases with age (93 subjects), correlates with decreasing cognitive ability and when it exceeds a unique critical level the subject is clinically diagnosed as having Alzheimer's disease. Aluminium accumulates in the human brain with age, increases the F - P value close to the critical value in a dose dependent manner, and at such a rate that normal environmental exposure to aluminium accounts for all or nearly all the F - P increases in man. Aluminium neurotoxicity is therefore a major cause of sporadic Alzheimer's disease.

Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences > Health Sciences
Additional Information: Abstract appearing in Pteridines 4:P99, 0933-4807
Event Title: 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines
Event Type: Other
Event Dates: 1993-02-01
Uncontrolled Keywords: flash-pattern evoked potential difference,cognitive ability,Alzheimer's disease,aluminium,brain,aluminium neurotoxicity
Published Date: 1993
Authors: Hodgkins, Paul S.
Blair, J.A.
Armstrong, Richard A.

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