The case for aluminium as the neurotoxin in sporadic Alzheimer's disease

Hodgkins, Paul S.; Blair, J.A. and Armstrong, Richard A. The case for aluminium as the neurotoxin in sporadic Alzheimer's disease. IN: 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines. 1993-02-01. (Unpublished)

Abstract

The flash-pattern evoked potential difference (F - P) in man increases with age (93 subjects), correlates with decreasing cognitive ability and when it exceeds a unique critical level the subject is clinically diagnosed as having Alzheimer's disease. Aluminium accumulates in the human brain with age, increases the F - P value close to the critical value in a dose dependent manner, and at such a rate that normal environmental exposure to aluminium accounts for all or nearly all the F - P increases in man. Aluminium neurotoxicity is therefore a major cause of sporadic Alzheimer's disease.

Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences > Health Sciences
Additional Information: Abstract appearing in Pteridines 4:P99, 0933-4807
Event Title: 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines
Event Type: Other
Event Dates: 1993-02-01
Uncontrolled Keywords: flash-pattern evoked potential difference,cognitive ability,Alzheimer's disease,aluminium,brain,aluminium neurotoxicity

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