Pattern visual evoked potentials in man and tetrahydrobiopterin metabolism

Edwards, P.; Cattell, R.J.; Blair, J.A. and Armstrong, Richard A. (1993). Pattern visual evoked potentials in man and tetrahydrobiopterin metabolism. IN: 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines. 1993-02-01. (Unpublished)

Abstract

The P2 visual evoked response in man has a cholinergic component while the P100 response has not. The P100 latency is significantly decreased after an oral dose of phenylalanine in man while the P2 signal is unaffected. Analyses of the P100 decrease shows no correlation with tyrosine levels but a significant positive correlation with plasma ane urine levels. A small group shows a P100 delay which correlated with increased neopterin levels only. Increased plasma total biopterins in man following a phenylalanine dose are due to rapidly increased tetrahydrobiopterin synthesis in the liver.

Divisions: Life & Health Sciences > Optometry
Additional Information: Abstract appearing in Pteridines 4:P96-97, 0933-4807.
Event Title: 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines
Event Type: Other
Event Dates: 1993-02-01
Uncontrolled Keywords: visual evoked response,P100,P2,plasma total biopterins,tetrahydrobiopterin synthesis,liver
Published Date: 1993

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