Distribution of A4 protein and neurofibrillary change in the hippocampus in Alzheimer's disease

Armstrong, Richard A.; Myers, D. and Smith, C.U.M. Distribution of A4 protein and neurofibrillary change in the hippocampus in Alzheimer's disease. IN: 8th International Meeting of the Brain Research Association. 1992-01-01 - 1992-01-01.

Abstract

The principal components of classical senile plaques (SP) in Alzheimer's disease (AD) appear to be A4/beta protein and paired helical filaments (PHF). A4 deposits may evolve into classical SP in brain regions vulnerable to the formation of PHF. We have investigated the diatribution of A4 deposits using an immunostain and the neurofibrillary change using the Gallyas stain in various regions of the hippocampus. This region is particularly affected in AD and also has relatively restricted inputs and outputs. In 6 patients we found a significant preponderance of A4 deposits in the adjacent parahippocampal gyrus (PHG) compared with all regions of the hippocampus. However, plaque-like clusters of PHF (Gallyas plaques) were more abundant in the subiculum while neurofibrillary tangles (NFT) were more abundant in the subiculum and region CA1 compared with the PHG and other hippocampal regions. Hence, A4 deposits appear to be concentrated in the region providing a major input into the hippocampus while the neurofibrillary changes are characteristic of the major output areas (subiculum and CA1). Hence, the data suggest that A4 formation and the neurofibrillary changes may occur in regions of the hippocampus that are connected anatomically.

Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences > Health Sciences
Additional Information: Abstract appearing in Euro. J. Neuro. Suppl. 4:P182.
Event Title: 8th International Meeting of the Brain Research Association
Event Type: Other
Event Dates: 1992-01-01 - 1992-01-01
Uncontrolled Keywords: classical senile plaques,Alzheimer's disease,A4/beta protein,paired helical filaments,brain

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