Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT)

Jones, S.A., Armstrong, Richard A., Blair, J.A., Leeming, R.J., Chaudhry, C., Swade, C. and Coppen, A. (1987). Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT). Biochemical Society Transactions, 15 (4), pp. 713-714.


Tetrahydrobiopterin is the cofactor required for the biosynthesis of the neurotransmitters and neuromodulators dopamine, noradrenaline and serotonin. The results show that in SDAT there is decreased conversion of dihydroneopterin triphosphate to tetrahydrobiopterin. Further measurements on strictly age-matched SDAT subjects and controls have confirmed the trends in this investigation.

Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Additional Information: 621st Meeting of the Biochemical Society, 1987, London (UK).
Uncontrolled Keywords: tetrahydrobiopterin,biosynthesis,neurotransmitters,neuromodulators dopamine,noradrenaline,serotonin
Full Text Link: http://www.biochemsoctrans.org/bst/default.htm
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Published Date: 1987
Authors: Jones, S.A.
Armstrong, Richard A. ( 0000-0002-5046-3199)
Blair, J.A.
Leeming, R.J.
Chaudhry, C.
Swade, C.
Coppen, A.

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