Peptide conjugate hydrogelators

Adams, Dave J. and Topham, Paul D. Peptide conjugate hydrogelators. Soft matter, 6 (16), pp. 3707-3721.

Abstract

Molecular gelators are currently receiving a great deal of attention. These are small molecules which, under the appropriate conditions, assemble in solution to, in the majority of cases, give long fibrillar structures which entangle to form a three-dimensional network. This immobilises the solvent, resulting in a gel. Such gelators have potential application in a number of important areas from drug delivery to tissue engineering. Recently, the use of peptide-conjugates has become prevalent with oligopeptides (from as short as two amino acids in length) conjugated to a polymer, alkyl chain or aromatic group such as naphthalene or fluorenylmethoxycarbonyl (Fmoc) being shown to be effective molecular gelators. The field of gelation is extremely large; here we focus our attention on the use of these peptide-conjugates as molecular hydrogelators.

Publication DOI: https://doi.org/10.1039/c000813c
Divisions: Engineering & Applied Sciences > Chemical engineering & applied chemistry
Engineering & Applied Sciences > Polymer Processing and Performance Research Unit
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Additional Information: © The Royal Society of Chemistry 2010
Uncontrolled Keywords: molecular gelators,molecules,drug delivery,tissue engineering,peptide-conjugates,oligopeptides,Chemistry(all),Condensed Matter Physics

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