Retinoblastoma and the new genetics

Armstrong, Richard A. and Smith, S.N. (1999). Retinoblastoma and the new genetics. Optometry Today, 1999 (March), pp. 43-47.


Wardop first described retinoblastoma in 1809. It is the most common intraocular tumour of childhood and the most common tumour of the retina. It was originally thought to be a glioma arising from glial cells of the retina. However, in 1926 it was recognised as a tumour of undifferentiated photoreceptor cells. This article describes the basic clinical and pathological aspects of retinoblastoma, the advances in molecular genetics which have led to the discovery of the gene responsible, and the defects which have been discovered in the retinoblastoma gene.

Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Life & Health Sciences > Biosciences
Uncontrolled Keywords: retinoblastoma,intraocular tumour,childhood,tumour,retina,undifferentiated photoreceptor cells,molecular genetics,gene,retinoblastoma gene
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Published Date: 1999-03-12
Authors: Armstrong, Richard A. ( 0000-0002-5046-3199)
Smith, S.N.

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