The relationship between the spatial pattern of senile plaques and neurofibrillary tangles in Alzheimer's disease

Armstrong, Richard A. (1990). The relationship between the spatial pattern of senile plaques and neurofibrillary tangles in Alzheimer's disease. Neuroscience Research Communications, 7 (2), pp. 105-111.

Abstract

The topographic pattern of senile plaques (SP) and neurofibrillary tangles (NFT) was studied in silver stained coronal sections of neocortex and hippocampus in ten cases of Alzheimer's disease (AD). Both lesions showed evidence of clustering in the tissue with many of the clusters being regularly spaced. The patterns of SP and NFT were compared 1) in the same cortical zone, 2) between upper and lower zones of the cortex and 3) in regions connected by either association fibres or the perforant path. Correlations between the lesions in the same cortical zone were found in 20% of the layers examined while correlations between upper and lower zones occurred in 64% of cortical regions examined. There was evidence that NFT in upper and lower cortex may be in register in some tissues. In addition, positive correlations were found between upper NFT and lower SP and negative correlations between upper SP and lower NFT in some tissues. Regular clustering of lesions was also observed in brain regions connected to one another suggesting that they develop on functinally related sets of neurons.

Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences > Health Sciences
Uncontrolled Keywords: senile plaques,neurofibrillary tangles,coronal sections,neocortex,hippocampus,Alzheimer's disease,clustering,tissue
Published Date: 1990

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