Principal components analysis of Alzheimer’s disease based on neuropathological data: A study of 79 patients

Armstrong, Richard A. (1992). Principal components analysis of Alzheimer’s disease based on neuropathological data: A study of 79 patients. Neuroscience Research Communications, 11 (1), pp. 1-9.

Abstract

A Principal Components Analysis of neuropathological data from 79 Alzheimer’s disease (AD) cases was performed to determine whether there was evidence for subtypes of the disease. Two principal components were extracted from the data which accounted for 72% and 12% of the total variance respectively. The results suggested that 1) AD was heterogeneous but subtypes could not be clearly defined; 2) the heterogeneity, in part, reflected disease onset; 3) familial cases did not constitute a distinct subtype of AD and 4) there were two forms of late onset AD, one of which was associated with less senile plaque and neurofibrillary tangle development but with a greater degree of brain atherosclerosis.

Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Uncontrolled Keywords: Alzheimer’s disease,principal components analysis,neuropathology,disease subtypes
Full Text Link: http://eu.wiley.com/WileyCDA/WileyTitle/productCd-NRC.html
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Published Date: 1992
Authors: Armstrong, Richard A. ( 0000-0002-5046-3199)

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