Alzheimer's disease: Are cellular neurofibrillary tangles linked to beta/A4 formation at the projection sites?

Armstrong, Richard A. (1992). Alzheimer's disease: Are cellular neurofibrillary tangles linked to beta/A4 formation at the projection sites? Neuroscience Research Communications, 11 (3), pp. 171-178.

Abstract

The density of senile plaques (SP) and cellular neurofibrillary tabgles (NFT) revealed by the Glees and Gallyas stains; and beta/A4 deposits revealed by immunocytochemical staining, was estimated in the hippocampus and adjacent gyri in Alzheimer's disease (AD). Stepwise multiple regression was used to detemine whether the density of cellular NFT was related to the density of SP or beta/A4 deposits totalled over the projection sites. Cellular NFT density was only weakly correlated with the density of Glees SP and beta/A4 deposits at some of the projection sites. However, beta/A4 deposit density in a tissue was strongly correlated with the density of beta/A4 deposits at the projection sites suggesting that the lesions could spread through the brain. Hence, although there is a strong correlation between the density of beta/A4 deposits in different parts of the hippocampal formation there is little association between SP or beta/A4 and cellular NFT. These results do not provide strong evidence that beta/A4 protein is the cause of the neuritc changes in AD.

Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Uncontrolled Keywords: Alzheimer's disease,beta/A4 deposits,senile plaques,neurofibrillary tangles,hippocampus,projection sites
Full Text Link: http://eu.wiley.com/WileyCDA/WileyTitle/productCd-NRC.html
Related URLs:
Published Date: 1992
Authors: Armstrong, Richard A. ( 0000-0002-5046-3199)

Export / Share Citation


Statistics

Additional statistics for this record