Laminar distribution of ballooned neurons and tau positive neurons with inclusions in patients with corticobasal degeneration

Armstrong, Richard A. (2000). Laminar distribution of ballooned neurons and tau positive neurons with inclusions in patients with corticobasal degeneration. Neuroscience Research Communications, 27 (2), pp. 85-93.

Abstract

The laminar distribution of ballooned neurons (BN) and tau positive neurons with inclusions (tau+ neurons) was studied in the frontal and temporal cortex in twelve patients with corticobasal degeneration (CBD). In the majority of brain areas, the density of BN and tau+ neurons was maximal in the lower and upper cortical laminae respectively. The densities of tau+ neurons in the upper and lower cortex were positively correlated. In the majority of brain areas, however, no correlations were observed between the densities of BN and tau+ neurons. The laminar distribution of the BN may reflect the degeneration of the feedback cortico-cortical and/or the efferent cortical pathways. By contrast, the distribution of the tau+ neurons may reflect the degeneration of the feed-forward cortico-cortical pathways. In addition, BN and tau+ neurons may arise as a result of distinct pathological processes.

Publication DOI: https://doi.org/10.1002/1520-6769(200009/10)27:2<85::AID-NRC1>3.0.CO;2-5
Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences > Health Sciences
Uncontrolled Keywords: corticobasal degeneration,ballooned neurons,tau positive neurons,laminar distribution,cortico-cortical pathways
Published Date: 2000-11-13

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