Reduced transferrin binding in Down syndrome:a route to senile plaque formation and dementia

Hodgkins, Paul S., Prasher, Vee, Farrar, Gill, Armstrong, Richard A., Sturman, Steven, Corbett, John and Blair, John A. (1993). Reduced transferrin binding in Down syndrome:a route to senile plaque formation and dementia. NeuroReport, 5 (1), pp. 21-24.

Abstract

Plasma transferrin binding in Down syndrome and Alzheimer's disease is significantly reduced compared with age matched controls and it was thought this may help elucidate a pathological time sequence for the onset of dementia in Down syndrome. In Down syndrome, there was a reduction in gallium and aluminium transferrin binding both with age and the onset of dementia. Non-transferrin bound gallium species were identified as non-transportable phosphate or silicate. Thus, the route of entry of metals into the brain must be via a transferrin mediated complex only. A clear sequence of pathological events has been demonstrated in Down syndrome which shows the pathway to development of plaques and dementia and this is believed to have an immunological origin.

Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Uncontrolled Keywords: plasma transferrin binding,down syndrome,Alzheimer's disease,pathological time sequence,onset of dementia,dementia,senile plaque,transferrin,Neuroscience(all)
Full Text Link: http://journals.lww.com/neuroreport/Abstract/1993/10000/Reduced_transferrin_binding_in_Down_syndrome__a.5.aspx
Related URLs: http://www.scopus.com/inward/record.url?scp=0027433772&partnerID=8YFLogxK (Scopus URL)
Published Date: 1993-10
Authors: Hodgkins, Paul S.
Prasher, Vee
Farrar, Gill
Armstrong, Richard A. ( 0000-0002-5046-3199)
Sturman, Steven
Corbett, John
Blair, John A.

Export / Share Citation


Statistics

Additional statistics for this record