Beta/A4 deposits and their relationship to senile plaques in Alzheimer's disease

Armstrong, Richard A. and Myers, D. (1992). Beta/A4 deposits and their relationship to senile plaques in Alzheimer's disease. NeuroReport, 3 (3), pp. 262-264.

Abstract

The density and spatial pattern of immunostained beta/A4 deposits and mature senile plaques (SP) stained by the Glees method were compared in Alzheimer's diseased brain. Thirty-seven percent of the variance in Glees SP density in a tissue could be explained by beta/A4. Both lesions were clustered with the beta/A4 clusters often larger than the Glees SP clusters. Beta/A4 and Glees SP cluster size were not correlated in a tissue. The size of Glees SP clusters was positively correlated with SP density but no correlation could be detected for beta/A4. Hence, the density and spatial pattern of beta/A4 deposits in most tissues did not predict the development of Glees SP.

Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Uncontrolled Keywords: density pattern,spatial pattern,immunostained beta/A4 deposits,mature senile plaques,Alzheimer's disease,brain
Full Text Link: http://journals.lww.com/neuroreport/Abstract/1992/03000/_beta__A4_deposits_and_their_relationship_to.12.aspx
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Published Date: 1992-03
Authors: Armstrong, Richard A. ( 0000-0002-5046-3199)
Myers, D.

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