Hypothesis: is Alzheimer's disease a metal-induced immune disorder?

Armstrong, Richard A., Winsper, S.J. and Blair, J.A. (1995). Hypothesis: is Alzheimer's disease a metal-induced immune disorder? Experimental Neurology, 4 (1), pp. 107-111.


A hypothesis that a metal-induced immune disorder may be involved in the pathogenesis of some forms of Alzheimer's disease (AD) is presented. The classical complement pathway is activated in AD and T cells and reactive microglia appear in the brain. Studies of metal induced autoimmunity and the use of compounds containing aluminium as vaccine adjuvants suggest that metals can activate complement and can be taken up by antigen presenting cells. The consequent immune response could contribute to neuronal damage, beta-amyloid deposition and cell death. The strengths and weaknesses of this hypothesis are discussed and tests of some aspects are proposed.

Publication DOI: https://doi.org/10.1006/neur.1995.0013
Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Uncontrolled Keywords: Alzheimer's disease,metals,aluminium,immune activation,major histocompatability locus antigens
Published Date: 1995-03
Authors: Armstrong, Richard A. ( 0000-0002-5046-3199)
Winsper, S.J.
Blair, J.A.


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