Beta-amyloid deposition in the medial temporal lobe in elderly non-demented brains and in Alzheimer's disease

Armstrong, Richard A. (1995). Beta-amyloid deposition in the medial temporal lobe in elderly non-demented brains and in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 6 (3), pp. 121-125.

Abstract

The density of diffuse, primitive, classic and compact β-amyloid (β/A4) deposits was estimated in the medial temporal lobe in elderly non-demented brains and in Alzheimer's disease (AD). In the non-demented cases, β/A4 deposits were absent in the hippocampus but in 8/14 cases they were present in the adjacent cortical regions. Variation in β/A4 deposition in the non-demented cases was large and overlapped with that of the AD cases. The ratio of mature to diffuse β/A4 deposits was greater in the non-demented than in the AD cases. In both the non-demented cases and AD, the β/A4 deposits were clustered with, in many tissues, a regular distribution of clusters along the cortex parallel to the pia. However, the mean cluster size of the deposits in the cortex was greater in AD than in the non-demented cases. These results suggest that the spread of β/A4 pathology between the modular units of the cortex and into the hippocampus could be important factors in the development of AD.

Publication DOI: https://doi.org/10.1159/000106933
Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Uncontrolled Keywords: β/A4 deposition,Alzheimer's disease,hippocampus,medial temporal lobe,non-demented brains,Geriatrics and Gerontology,Neuropsychology and Physiological Psychology
Full Text Link: http://content.karger.com/ProdukteDB/produkte.asp?typ=pdf&doi=106933
Related URLs: http://www.scopus.com/inward/record.url?scp=0029033926&partnerID=8YFLogxK (Scopus URL)
Published Date: 1995
Authors: Armstrong, Richard A. ( 0000-0002-5046-3199)

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