Aluminium and Alzheimer's disease: review of possible pathogenic mechanisms

Armstrong, Richard A.; Winsper, S.J. and Blair, J.A. (1996). Aluminium and Alzheimer's disease: review of possible pathogenic mechanisms. Dementia and Geriatric Cognitive Disorders, 7 (1), pp. 1-9.

Abstract

Chronic exposure to aluminium (Al) remains a controversial possible cause of sporadic forms of Alzheimer's disease (AD). This article reviews the evidence that once Al enters the brain and individual brain cells, it may be involved in three pathological processes: (1) the production of abnormal forms of tau leading to the formation of cellular neurofibrillary tangles and neuropil threads; (2) the processing of the amyloid precursor protein, resulting in the formation of beta-amyloid deposits and senile plaques, and (3) that via the mutual histocompatibility system, Al could be involved in the initiation of the immune response observed in AD patients. Despite recent evidence that Al could be involved in these processes, a conclusive case that exposure to Al initiates the primary pathological process in sporadic AD remains to be established.

Publication DOI: https://doi.org/10.1159/000106845
Divisions: Life & Health Sciences > Optometry
Uncontrolled Keywords: Alzheimer's disease,aluminium,tau,amyloid precursor protein,immune reaction
Published Date: 1996

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