Spatial distribution of diffuse, primitive, and classic amyloid-beta deposits and blood vessels in the upper laminae of the frontal cortex in Alzheimer disease

Armstrong, Richard A., Cairns, Nigel J. and Lantos, Peter L. (1998). Spatial distribution of diffuse, primitive, and classic amyloid-beta deposits and blood vessels in the upper laminae of the frontal cortex in Alzheimer disease. Alzheimer Disease and Associated Disorders, 12 (4), pp. 378-383.

Abstract

The spatial distribution of the diffuse, primitive, and classic amyloid-beta deposits was studied in the upper laminae of the superior frontal gyrus in cases of sporadic Alzheimer disease (AD). Amyloid-beta-stained tissue was counterstained with collagen IV to determine whether the spatial distribution of the amyloid-beta deposits along the cortex was related to blood vessels. In all patients, amyloid-beta deposits and blood vessels were aggregated into distinct clusters and in many patients, the clusters were distributed with a regular periodicity along the cortex. The clusters of diffuse and primitive deposits did not coincide with the clusters of blood vessels in most patients. However, the clusters of classic amyloid-beta deposits coincided with those of the large diameter (>10 microm) blood vessels in all patients and with clusters of small-diameter (< 10 microm) blood vessels in four patients. The data suggest that, of the amyloid-beta subtypes, the clusters of classic amyloid-beta deposits appear to be the most closely related to blood vessels and especially to the larger-diameter, vertically penetrating arterioles in the upper cortical laminae.

Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Uncontrolled Keywords: spatial distribution,amyloid-beta deposit,upper laminae,superior frontal gyrus,sporadic Alzheimer disease,Amyloid-beta-stained tissue,cortex,blood vessels,clustering
Full Text Link: http://journals.lww.com/alzheimerjournal/Abstract/1998/12000/Spatial_Distribution_of_Diffuse,_Primitive,_and.21.aspx
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Published Date: 1998-12
Authors: Armstrong, Richard A. ( 0000-0002-5046-3199)
Cairns, Nigel J.
Lantos, Peter L.

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