A quantitative study of the pathological lesions in the neocortex and hippocampus of twelve patients with corticobasal degeneration

Armstrong, Richard A., Cairns, Nigel J. and Lantos, Peter L. (2000). A quantitative study of the pathological lesions in the neocortex and hippocampus of twelve patients with corticobasal degeneration. Experimental Neurology, 163 (2), pp. 348-356.


The density of ballooned neurons (BN), tau-positive neurons with inclusion bodies (tau+ neurons), and tau-positive plaques (tau+ plaques) was determined in sections of the frontal, parietal, and temporal lobe in 12 patients with corticobasal degeneration (CBD). No significant differences in the mean density of BN and tau+ neurons were observed between neocortical regions. In the hippocampus, the densities of BN were significantly lower than in the neocortex, and densities of tau+ neurons were greater in sectors CA1 and CA2, compared with CA3 and CA4. Tau+ plaques were present in one or more brain regions in six patients. Significantly more BN were recorded in the lower (laminae V/VI) compared with the upper cortex (laminae I/II/III) but tau+ neurons were equally frequent in the upper and lower cortex. No significant correlations were observed between the densities of BN and tau+ neurons, but the densities of BN in the superior temporal gyrus and tau+ plaques in the frontal cortex were positively correlated with age. A principal components analysis (PCA) suggested that differences in the density of tau+ neurons in the frontal and motor cortex were the most important sources of variation between patients. In addition, one patient with a particularly high density of tau+ neurons in the hippocampus appeared to be atypical of the patient group studied. The data support the hypothesis that, although clinically heterogeneous, CBD is a pathologically distinct disorder. (C) 2000 Academic Press.

Publication DOI: https://doi.org/10.1006/exnr.2000.7392
Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Uncontrolled Keywords: corticobasal degeneration,ballooned neurons,Tau positive neurons,Tau positive plaques,paired helical filaments,Pick's disease
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Related URLs: http://www.scopus.com/inward/record.url?scp=0034044177&partnerID=8YFLogxK (Scopus URL)
Published Date: 2000-06
Authors: Armstrong, Richard A. ( 0000-0002-5046-3199)
Cairns, Nigel J.
Lantos, Peter L.


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