Clinical evaluation of the Macuscope macular pigment densitometer

Bartlett, Hannah E.; Acton, Jennifer H. and Eperjesi, Frank Clinical evaluation of the Macuscope macular pigment densitometer. British Journal of Ophthalmology, 94 (3), pp. 328-331.

Abstract

Background/aims. The MacuScope uses a psychophysical technique called heterochromic flicker photometry to measure macular pigment optical density (MPOD). Our aim was to determine the measurement variability (noise) of the MacuScope. Methods. Thirty-eight normally sighted participants who ranged in age from 19 to 46 years (25.7±7.6 years) were recruited from staff and students of Aston University. Data were collected by two operators, HB and JA, in two sessions separated by 1 week in order to assess test repeatability and reproducibility. Results. The overall mean MPOD for the cohort was 0.47±0.14. There was a significant negative correlation between MacuScope MPOD readings and age (r=-0.368, p=0.023). Coefficients were 0.45 and 0.58 for repeatability, and 0.49 and 0.36 for reproducibility. For each pair of results, there was a significant positive correlation between mean and difference MPOD values. Conclusions. If MPOD is being monitored over time then any change less than 0.58 units should not be considered clinically significant as it is very likely to be due to instrument noise. The size of the coefficient appears to be positively correlated with MPOD.

Publication DOI: https://doi.org/10.1136/bjo.2009.167213
Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences > Health Sciences
Life & Health Sciences > Applied Health Research Group
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Additional Information: Copyright of BMJ Publishing Group.
Uncontrolled Keywords: MacuScope,heterochromic flicker photometry,macular pigment optical density,measurement variability,Ophthalmology,Cellular and Molecular Neuroscience,Sensory Systems

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