Calcitonin gene-related peptide:multiple actions, multiple receptors

Poyner, David R. (1992). Calcitonin gene-related peptide:multiple actions, multiple receptors. Pharmacology and Therapeutics, 56 (1), pp. 23-51.


Calcitonin gene-related peptide (CGRP) shows diversity both in its effects and its receptors. It is likely to have roles as a neurotransmitter, neuromodulator, local hormone and trophic factor. Its effects include rapid changes in neuronal activity, relaxation of many type of smooth muscle, actions on metabolism and changes in gene expression. Receptor heterogenecity has been revealed from experiments comparing agonist potency ratios and antagonists affinities. the evidence from these approaches is reviewed in this article and a speculative receptor classification scheme is proposed. Some of the likely future directions for CGRP research are discussed. © 1993.

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Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Life & Health Sciences > Applied Health Research Group
Life & Health Sciences > Biomedical Sciences research group
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Uncontrolled Keywords: amino acid sequence,animals,calcitonin,gene-related peptide,humans,molecular sequence data receptors,calcitonin receptors,cell surface,Psychology(all)
Published Date: 1992


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