Organic reactions in ionic liquids: Knoevenagel condensation catalyzed by ethylenediammonium diacetate

Su, Ce, Chen, Zhen-Chu and Zheng, Qinguo (2003). Organic reactions in ionic liquids: Knoevenagel condensation catalyzed by ethylenediammonium diacetate. Synthesis, 2003 (4), pp. 555-559.

Abstract

The moisture and air stable ionic liquids 1-butyl-3-methylimidazonium tetrafluoroborate [bmim]BF4 and 1-butyl-3-methylimidazonium hexafluorophosphate [bmim]PF6 were used as ‘green' recyclable alternatives to volatile organic solvents (VOCs) for ethylenediammonium diacetate (EDDA) catalyzed Knoevenagel condensation between aldehydes or ketones with active methylene compounds. Both aldehydes and ketones gave satisfactory results. The ionic liquids containing catalyst EDDA were recycled several times with no decreases in yields and reaction rates. In the case of 2-hydroxybenzaldehyde, the reactions led to the formation of 3-substituted coumarins under standard reaction conditions.

Publication DOI: https://doi.org/10.1055/s-2003-37643
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Uncontrolled Keywords: ionic liquid,condensation,ketones,aldehydes,Knoevenagel reaction,active methylene compounds
Full Text Link: https://www.thi ... 55/s-2003-37643
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Published Date: 2003-03
Authors: Su, Ce
Chen, Zhen-Chu
Zheng, Qinguo

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